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Which statement about nonsteroidal antiinflammatory drugs (NSAIDs) is true?

  1. They depress the central nervous system

  2. They inhibit prostaglandin synthesis

  3. They are highly recommended for older adults

  4. They are the most effective prescription medication for pain

The correct answer is: They inhibit prostaglandin synthesis

Nonsteroidal antiinflammatory drugs (NSAIDs) are well-recognized for their role in pain management, primarily due to their mechanism of action. They work by inhibiting the synthesis of prostaglandins, which are lipid compounds that play a crucial role in mediating inflammation, pain, and fever. By reducing the production of these substances, NSAIDs effectively alleviate pain, particularly that which is associated with inflammation. The inhibition of prostaglandin synthesis is particularly important in conditions such as arthritis or other inflammatory diseases, where pain and swelling are prevalent. This mechanism not only provides analgesic effects but also reduces inflammation, which is beneficial for overall patient comfort and mobility. While NSAIDs are commonly used and can be effective for a variety of pain types, they have specific precautions associated with their use, especially in older adults and those with certain health conditions. Understanding their mechanisms helps healthcare providers select the appropriate pain management strategies tailored to individual patient needs.